| 摘要 |
Provided are dihydroquinazolinone derivative compounds of the formula (I’), wherein the variables are as defined in the specification. Examples of the compounds include 3-({ 4-hydroxy-1-[3-(2-methoxyphenyl)propanoyl]piperidin-4-yl} methyl)-3,4-dihydroquinazolin-4-one and 3-{ [1-(2-benzylpropanoyl)-4-hydroxypiperidin-4-yl)methyl} -7-chloro-3,4-dihydroquinazolin-4-one. The compounds are selective and reversible inhibitors of ubiquitin specific protease 7. The compounds may be useful in the treatment of cancer, neurodegenerative diseases, inflammatory disorders and viral infections. |
