发明名称 |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
摘要 |
Disclosed are compounds having Formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein. In one embodiment, the compound of Formula (I) is 6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-pyrazol-4-yl)pyridine-2-carboxylic acid. |
申请公布号 |
NZ623068(A) |
申请公布日期 |
2016.07.29 |
申请号 |
NZ20120623068 |
申请日期 |
2012.10.11 |
申请人 |
ABBVIE INC. |
发明人 |
SOUERS ANDREW;HANSEN TODD M.;WANG LE;DOHERTY GEORGE;WANG XILU;TAO ZHI-FU;BRUNKO MILAN;KUNZER AARON R.;WENDT MICHAEL D.;SONG XIAOHONG;FREY ROBIN;SULLIVAN GERARD M.;JUDD ANDREW |
分类号 |
C07D215/58;A61K45/06;C07D417/04;C07D417/14 |
主分类号 |
C07D215/58 |
代理机构 |
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