| 摘要 |
A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.; |
| 主权项 |
1. A compound represented by the following formula [1F]: (wherein R1 represents a hydroxyl-protecting group; R2 represents a hydroxyl-protecting group; or R1 and R2 may together form an optionally substituted C1-3 alkylene group; and R3C represents a hydrogen atom, a halogen atom, a group represented by the following formula [16]:
OR3a [16┘ (wherein R3a represents a hydroxyl-protecting group), or an optionally substituted C1-6 alkyl group; R3D represents a hydrogen atom, a halogen atom, a group represented by the following formula [16]
OR3a [16┘ (wherein R3a has the same meanings as those described above), or an optionally substituted C1-6 alkyl group; R4 represents a halogen atom, a hydroxyl group, an optionally substituted C1-6 alkylsulfonyloxy group or an optionally substituted arylsulfonyloxy group; R5 and R6 together represent a group represented by the following formula [2]:
═Y [2┘ (wherein Y represents an oxygen atom or a group represented by the following formula [3]:
═N—OR7 [3┘ (wherein R7 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclic group or an optionally substituted silyl group)); or R4 and R5 together represent a sulfur atom; and R6 represents a hydroxyl group, provided that, when R5 and R6 together represent a group represented by the following formula [2a]:
═O [2a┘, one of R3C and R3D represents a halogen atom, the other represents a hydrogen atom, and R4 represents a halogen atom, an optionally substituted C1-6 alkylsulfonyloxy group or an optionally substituted arylsulfonyloxy group; when R4 and R5 together represent a sulfur atom and one of R3C and R3D represents a hydrogen atom, the other represents a halogen atom, or an optionally substituted C1-6 alkyl group; when R5 and R6 together represent a group represented by the following formula [3]:
═N—OR7 [3┘ (wherein R7 has the same meanings as those described above), one of R3C and R3D represents a group represented by the following formula [16]:
OR3a [6┘ (wherein R3a has the same meanings as those described above), the other represents a hydrogen atom, and R4 represents an iodine atom, a hydroxyl group, an optionally substituted C1-6 alkylsulfonyloxy group or an optionally substituted arylsulfonyloxy group, R1 represents an optionally substituted acyl group, and R2 represents an optionally substituted acyl group; and when R5 and R6 together represent a group represented by the following formula [3]:
═N—OR7 [3┘ (wherein R7 has the same meanings as those described above), one of R3C and R3D represents a hydrogen atom, the other represents a hydrogen atom, and R4 represents a hydroxyl group, R1 represents an optionally substituted aroyl group, and R2 represents an optionally substituted aroyl group). |
