发明名称 |
ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS |
摘要 |
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically acceptable salts or solvates thereof, wherein: A is an antibody that selectively binds Endoglin; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed. |
申请公布号 |
EP3102606(A2) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20150705779 |
申请日期 |
2015.02.04 |
申请人 |
Oncomatryx Biopharma, S.L. |
发明人 |
KONTERMANN, Roland;PFIZENMAIER, Klaus;FERRER, Cristina;FABRE, Myriam;SIMON, Laureano |
分类号 |
C07K16/28;A61K47/48 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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