METHOD FOR ENHANCING OF IMMUNE RESPONSE IN NUCLEIC ACID VACCINATION

摘要

FIELD: medicine. ^ SUBSTANCE: invention relates to composition for simultaneous delivery of nucleic acid and auxiliary protein into cell containing vesicles, nucleic acid and protein, wherein nucleic acid functionally encodes antigen protein or part thereof having at least one conjoint epitope with auxiliary protein and composition contains nucleic acid and auxiliary protein associated with the same vesicles. In preferred embodiment composition contains lyposomes formed from liposome-forming materials and nucleic acid associated with lyposomes. Also disclosed are method for formation of immune response in animal by administering of abovementioned composition and method for production of lyposomal composition. ^ EFFECT: composition useful as vaccine. ^ 15 cl, 6 ex, 15 tbl, 10 dwg