发明名称 |
BENZOISOTHIAZOLE COMPOUNDS AND USE IN PREPARATION OF ANTIPSYCHOTIC DRUGS |
摘要 |
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D 3 receptor, 5-HT 1A receptor and 5-HT 2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof. |
申请公布号 |
EP2995617(A4) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20140794060 |
申请日期 |
2014.05.08 |
申请人 |
Shanghai Institute of Pharmaceutical Industry |
发明人 |
LI, Jianqi;CHEN, Xiaowen;MA, Zhilong;ZHANG, Li;CUI, Ning |
分类号 |
C07D417/12;A61K31/496;A61P25/00;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;C07D275/04 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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