CELL-PERMEABLE, CELL-COMPATIBLE, AND CLEAVABLE LINKERS FOR COVALENT TETHERING OF FUNCTIONAL ELEMENTS

摘要

Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.

主权项

1. A dual-function, cell-permeable, cell-compatible, chemoselectively-cleavable composition, comprising:
(a) a cellular interaction element; (b) a capture element; and (c) a linker covalently tethering the cellular interaction element to the capture element, wherein said linker comprises a chemoselectively cleavable moiety.