| 发明名称 |
Agonists and antagonists of toll-like receptor (TLR) 13 |
| 摘要 |
The present invention relates to the field of immunology. The present invention provides agonists and antagonists of Toll-like receptor (TLR) 13. In particular, the present invention provides TLR13 activating and inhibiting nucleic acids, and provides such nucleic acids for use as pharmaceutical agents. The present invention further provides in vitro methods using such nucleic acids. |
| 申请公布号 |
US9556439(B2) |
申请公布日期 |
2017.01.31 |
| 申请号 |
US201314377035 |
申请日期 |
2013.02.08 |
| 申请人 |
BAVARIAN NORDIC A/S |
发明人 |
Kirschning Carsten;Bauer Stefan;Hochrein Hubertus |
| 分类号 |
C12N15/117;A61K39/39;C12N15/113;A61K31/7105;A61K39/085;A61K39/09 |
主分类号 |
C12N15/117 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for modulating Toll-like receptor-13 (TLR-13) or Toll-like receptor-13 (TLR-13)-expressing cells in a subject, comprising: administering to the subject a pharmaceutical agent comprising SEQ ID NO:1, SEQ ID NO: 13, SEQ ID NO:15, or a functional variant thereof, wherein the functional variant thereof is capable of: (1) activating TLR-13; (2) activating TLR-13 expressing cells; or (3) is capable of stimulating an immune response in a non-primate subject. |
| 地址 |
Kvistgaard DK |
