Mutant delta-9 elongases and their use in making polyunsaturated fatty acids

摘要

Mutant delta-9 elongases having the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA] and/or a-linolenic [18:3, ALA] to eicosatrienoic acid [20:3, ETrA] are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant delta-9 elongases, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"] using these mutant delta-9 elongases in oleaginous yeast are also disclosed.