发明名称 |
Methods for compositions for in vivo gene delivery |
摘要 |
Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or complexed to lipid carriers, particularly cationic lipid carriers. Multiple individual tissues can be transfected using naked DNA. Using a DNA:lipid carrier complex, multiple tissues and cell types can be transfected. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.
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申请公布号 |
US6806084(B1) |
申请公布日期 |
2004.10.19 |
申请号 |
US19980090030 |
申请日期 |
1998.06.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DEBS ROBERT JAMES;ZHU NING |
分类号 |
A61K9/127;A61K38/00;A61K39/00;A61K47/48;A61K48/00;C07K14/00;C07K14/47;C07K14/55;C12N15/88;(IPC1-7):C12N15/63 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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