发明名称 |
2,6-DIAMINO-PYRIMIDIN-5-YL-CARBOXAMIDES AS SYK OR JAK KINASE INHIBITORS |
摘要 |
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation,and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma. |
申请公布号 |
CA2723205(C) |
申请公布日期 |
2017.03.14 |
申请号 |
CA20092723205 |
申请日期 |
2009.04.16 |
申请人 |
PORTOLA PHARMACEUTICALS, INC. |
发明人 |
BAUER, SHAWN M.;JIA, ZHAOZHONG J.;SONG, YONGHONG;XU, QING;MEHROTRA, MUKUND;ROSE, JACK W.;HUANG, WOLIN;VENKATARAMANI, CHANDRASEKAR;PANDEY, ANJALI |
分类号 |
C07D239/48;A61K31/506;A61P9/00;A61P35/00;C07D401/12;C07D403/12;C07D413/12;C07D417/12 |
主分类号 |
C07D239/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|