发明名称 |
Usos de un péptido aromático catiónico |
摘要 |
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p m ) and the total number of amino acid residues (r) wherein 3p m is the largest number that is less than or equal to r + 1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p t ) wherein 2a is the largest number that is less than or equal to p t + 1, except that when a is 1, p t may also be 1. |
申请公布号 |
ES2605504(T3) |
申请公布日期 |
2017.03.14 |
申请号 |
ES20140186875T |
申请日期 |
2004.02.03 |
申请人 |
Cornell Research Foundation, Inc.;Clinical Research Institute of Montreal |
发明人 |
Szeto, Hazel H;Zhao, Kesheng;Schiller, Peter W |
分类号 |
A61K38/03;A61K38/07;A61K38/08;A61K38/10;C07K5/00;C07K5/10;C07K5/103;C07K5/107;C07K5/11;C07K5/117;C12Q |
主分类号 |
A61K38/03 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|