| 发明名称 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases | ||
| 摘要 | Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | ||
| 申请公布号 | US9593322(B2) | 申请公布日期 | 2017.03.14 |
| 申请号 | US201514593620 | 申请日期 | 2015.01.09 |
| 申请人 | aTyr Pharma, Inc.;Pangu BioPharma Limited | 发明人 | Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain P.;Lo Wing-Sze;Watkins Jeffry D.;Quinn Cheryl L.;Mendlein John D. |
| 分类号 | C12N9/00;C12N9/10;A61K38/53;C07K16/40;G01N33/573;A61K39/00;A61K38/00 | 主分类号 | C12N9/00 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. An isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide that is at least 95% identical to SEQ ID NO:29, or a fragment thereof which is 60 or more contiguous amino acids of SEQ ID NO:29, wherein the polypeptide has an extracellular signalling activity, and wherein the polynucleotide is selected from (a) cDNA polynucleotide and (b) a modified mRNA polynucleotide. | ||
| 地址 | San Diego CA US | ||