| 发明名称 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases | ||
| 摘要 | Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | ||
| 申请公布号 | US9593323(B2) | 申请公布日期 | 2017.03.14 |
| 申请号 | US201514687760 | 申请日期 | 2015.04.15 |
| 申请人 | aTyr Pharma, Inc.;Pangu BioPharma Limited | 发明人 | Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain P.;Lo Wing-Sze;Watkins Jeffry D.;Quinn Cheryl L.;Mendlein John D. |
| 分类号 | C12P7/44;C12P13/02;C12P7/24;C08G69/28;C12N9/00;A61K38/53;C07K16/40;C12N5/071;C12N9/96;G01N33/68;G01N33/573 | 主分类号 | C12P7/44 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. An isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide which consists of a sequence that is at least 95% identical to SEQ ID NO:45, 43, 19, or 12, or a fragment thereof which is 120 or more contiguous amino acids of SEQ ID NO: 45, 43, 19, or 12, wherein the AARS polypeptide has an extracellular signaling activity, and wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide. | ||
| 地址 | San Deigo CA US | ||