In situ system for intra-articular chondral and osseous tissue repair

摘要

Disclosed is a device and method which provide a surgical therapy for in situ treatment and repair of intra-articular cartilage lesions and/or defects. The device is an implantable laminate cartilage repair patch which is bio-compatible and physiologically absorbable. The cartilage repair patch has a first outer cell occlusive layer; a second outer, cell porous layer adapted to be disposed proximate a subchondral bone wound site; and a cartilagenic matrix disposed between the first and second layers. The cartilagenic matrix is a sink for diffusion of autologous stem cells and includes chemical components promoting generation of hyaline-like cartilage in the presence of the autologous stem cells. The method of the present invention provides the autologous compositions, which when used in combination with the repair patch provides a therapeutic system to regenerate replacement hyaline-like intraarticular cartilage.

主权项

1. A laminate cartilage repair patch that is bio-compatible and physiologically absorbable for in situ cartilage repair in intra-articular lesions, comprising
(1) a basement layer that is cell-porous and consists of sheet collagen; and (2) a cartilagenic matrix layer disposed on the basement layer, wherein the cartilagenic matrix layer is:
a porous composite pad that consists of (a) collagen, (b) natural hyaluronic acid (HA), and (c) a chemical composition selected from the group consisting of natural hyaluronic acid (HA), Diacerein, Rhein, poly-lactic acid, somatotropine, and chitosan,wherein the porous composite pad is interspersed with non-human collagen fibers and said natural hyaluronic acid, and has embedded therein the chemical composition of (c);wherein the laminate cartilage repair patch is flexible.