Method and system for non-invasive computation of hemodynamic indices for coronary artery stenosis

摘要

A method and system for non-invasive hemodynamic assessment of coronary artery stenosis based on medical image data is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient. Patient-specific boundary conditions of a computational model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements of the coronary arteries. Blood flow and pressure in the coronary arteries are simulated using the computational model of coronary circulation and the patient-specific boundary conditions and coronary autoregulation is modeled during the simulation of blood flow and pressure in the coronary arteries. A wave-free period is identified in a simulated cardiac cycle, and an instantaneous wave-Free Ratio (iFR) value is calculated for a stenosis region based on simulated pressure values in the wave-free period.

主权项

1. A method for hemodynamic assessment of a coronary artery based on medical image data of a patient, comprising:
extracting patient-specific anatomical measurements of the coronary arteries from medical image data of a patient; calculating patient-specific boundary conditions of a computational model of coronary circulation representing the coronary arteries based on the patient-specific anatomical measurements of the coronary arteries; simulating blood flow and pressure in the coronary arteries using the computational model of coronary circulation and the patient-specific boundary conditions and modeling coronary autoregulation during the simulation of blood flow and pressure in the coronary arteries, wherein modeling coronary autoregulation during the simulation of blood flow and pressure in the coronary arteries comprises:
adapting microvascular resistances at outlets of the computational model of coronary circulation downstream of each coronary artery stenosis in the computational model of coronary circulation based on a simulated pressure drop over the coronary artery stenosis, a simulated flow rate through the coronary artery stenosis, and flow rate split ratios calculated for branches in the coronary artery tree downstream of the coronary artery stenosis; and calculating a hemodynamic index for at least one region in the coronary arteries based on the simulated blood flow and pressure.