| 发明名称 |
PROCESS FOR FLUORINATING COMPOUNDS |
| 摘要 |
Disclosed are mild temperature (e.g., from 0 to 80° C.) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F. |
| 申请公布号 |
US2017066721(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201615228188 |
申请日期 |
2016.08.04 |
| 申请人 |
Dow AgroSciences LLC ;The Regents of the University of Michigan |
发明人 |
Sanford Melanie;Ryan Sarah;Schimler Sydonie;Cheng Yang;Bland Douglas |
| 分类号 |
C07D213/79;C07D215/04;C07D213/76;C07D237/08;C07D213/84;C07D213/85;C07D213/803;C07D217/02 |
主分类号 |
C07D213/79 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a fluorinated aryl or heteroaryl substrate, comprising:
combining tetramethylammonium fluoride and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, iodo, nitro, or sulfonate group, at from 0° C. to 80° C. |
| 地址 |
Indianapolis IN US |
