Compositions and Methods to Treat Vision Disorders

摘要

The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.

主权项

1. A method to treat or prevent a vision disorder in a subject in need thereof, said method comprises administrating to at least one eye of the subject a composition comprising a pharmaceutically acceptable ophthalmic carrier and a pharmaceutically effective amount of lanosterol, wherein said lanosterol inhibits crystallin protein aggregation or dissolves crystallin protein aggregate in the eye of said subject.