Non-Systemic Topical Compositions Comprising Corticosteroids

摘要

Described herein are topical, non-systemic, slow releasing oral pharmaceutical compositions, methods for making the same, and methods for treating subjects in need thereof with such compositions. In particular, the oral composition provides topical, non-systemic administration of one or more active pharmaceutical ingredients to the oral cavity and upper gastrointestinal track, including the esophagus. In one embodiment, the pharmaceutical composition provides topical corticosteroids to the esophagus and oral cavity.

主权项

1. A topical, non-systemic, oral, slow releasing pharmaceutical composition comprising:
(a) about 1% to about 5% by mass of one or more release modifiers; (b) about 10% to about 60% by mass of one or more film-forming polymers; (c) about 5% to about 20% by mass of one or more plasticizers; and (d) less than 1% by mass of one or more active pharmaceutical ingredients.