| 发明名称 |
NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME |
| 摘要 |
The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a Filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds. |
| 申请公布号 |
US2017114060(A1) |
申请公布日期 |
2017.04.27 |
| 申请号 |
US201515315038 |
申请日期 |
2015.06.03 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
FREEDMAN Bruce D.;HARTY Ronald N.;REITZ Allen B.;WROBEL Jay E. |
| 分类号 |
C07D473/34;A61K45/06;A61K31/455;A61K31/497;C07D231/12;A61K31/415;C07D413/12;A61K31/422;C07D401/12;A61K31/4439;C07D409/12;A61K31/4155;C07D417/12;A61K31/433;C07D471/04;A61K31/437;C07D401/14;A61K31/444;C07D233/64;A61K31/4164;C07C233/81;A61K31/167;C07D213/81;A61K31/44;C07C233/66;C07D333/38;A61K31/381;C07D277/46;A61K31/426;C07D417/04;C07D235/10;A61K31/4184;C07D403/04;C07D417/14;A61K31/506;C07D295/192;A61K31/5375;C07D403/12;A61K31/4178;A61K31/4192;C07D473/04;A61K31/69 |
主分类号 |
C07D473/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or preventing a viral infection in a subject in need thereof, the method comprising administering to subject an effective amount of at least one inhibitor of a channel selected from the group consisting of calcium-release activated calcium (CRAC) channel and transient receptor potential mucolipin I (TRPML1) channel, whereby the viral infection is treated or prevented in the subject. |
| 地址 |
Philadelphia PA US |
