SYSTEMS, METHODS, AND VISUALIZATION TOOLS FOR STIMULATION AND SENSING OF NEURAL SYSTEMS WITH SYSTEM-LEVEL INTERACTION MODELS

摘要

A computer implemented system and method generates a patient-specific model of patient response to stimulation on a neural element basis, receives user-input of target neuromodulation sites, and, based on the patient-specific model, determines which stimulation paradigm and settings, including stimulation sites, would result in the target neuromodulation, where the stimulation sites are not necessarily the same as the resulting neuromodulation sites. The system outputs a visual representation of the stimulation sites that would result in the target neuromodulation. The system monitors a system state and/or patient state and dynamically changes which stimulation program to implement based on the state.

主权项

1. A computer-implemented method comprising:
receiving, by a processor and for each of a plurality of candidate stimulation sites, an indication of an indirect neuromodulation response for direct stimulation at each other of the candidate stimulation sites, wherein each of the candidate stimulation sites represents a portion of a brain that is distant from each other of the candidate stimulation sites; receiving, by a processor, a user-input of a desired stimulation response; determining, by the processor using the indications of the indirect neuromodulation responses for the candidate stimulation sites, at least one of the candidate stimulation sites for implantation of at least one electrode leadwire to stimulate the determined at least one of the candidate stimulation sites; determining or receiving, by the processor, electrode neuromodulation settings for performing neuromodulation on the brain of a patient using the at least one electrode leadwire implanted at the determined at least one of the candidate stimulation sites; and communicating the electrode neuromodulation settings for reception by an implantable pulse generator to perform neuromodulation in the brain of the patient using the at least one electrode leadwire coupled to the implantable pulse generator.