发明名称 |
Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods Of Making And Using Same |
摘要 |
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. |
申请公布号 |
US2017119672(A1) |
申请公布日期 |
2017.05.04 |
申请号 |
US201715406042 |
申请日期 |
2017.01.13 |
申请人 |
Pfizer Inc. |
发明人 |
Figueiredo Maria;Peeke Erick;Dewitt David;Van Geen Hoven Christina;Troiano Greg;Wright James;Song Young-Ho;Wang Hong |
分类号 |
A61K9/16;A61K31/506;A61K31/404 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
1. A therapeutic nanoparticle comprising:
about 0.05 to about 30 weight percent of a substantially hydrophobic acid; about 0.2 to about 20 weight percent of a basic therapeutic agent having a protonatable nitrogen; wherein the pKa of the basic therapeutic agent is at least about 1.0 pKa units greater than the pKa of the hydrophobic acid; and about 50 to about 99.75 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic acid-co-glycolic acid)-poly(ethylene)glycol copolymer, wherein the therapeutic nanoparticle comprises about 10 to about 30 weight percent poly(ethylene)glycol. |
地址 |
New York NY US |