Flavonoid compounds of low toxicity for biological imaging applications

摘要

Flavonoid compounds that are selective for a protein, a portion or a living cell, or a portion of an organism may be used as biological imaging agents. The flavonoid compounds are useful for methods of imaging organisms such as zebrafish embryos and zebra fish. Flavonoid compounds may also be used to detect protein. Advantageously, flavonoids that selectively bind protein, a portion of a living cell, or a portion of an organism may exhibit a florescence “turn-on” mechanism, where the flavonoids that are selectively bound exhibit a florescence response when excited.

主权项

1. A flavonoid compound for imaging zebrafish embryos, zebrafish larva, and/or zebrafish blood vessels, where the flavonoid compound is defined by the formula where each R1-R4 is individually an organic group or a hydrogen atom and X is a halogen atom.