pH-sensitive polymer-drug conjugates for targeted delivery of therapeutics

摘要

Polymeric delivery systems for boronic acid-containing therapeutics, related compounds and methods of use, for a pH-sensitive chemoselective approach to delivery of such a therapeutic.

主权项

1. A method of using a polymeric carrier component to affect efficacy of a therapeutic agent, said method comprising:
providing a therapeutic agent comprising a boronic acid moiety; conjugating a polymeric carrier component with said therapeutic agent, said polymeric carrier component comprising repeating lysine monomeric units, each said lysine monomeric unit coupled to a catecholic component and each said catecholic component coupled to a said therapeutic agent, said conjugation via a reversible pH-sensitive bond between a dihydroxyphenyl moiety of said catecholic component and said boronic acid moiety; and introducing said conjugated polymeric carrier component to a cellular environment comprising a pH at least sufficient to dissociate said therapeutic agent therefrom.