| 发明名称 | Octahydrocyclopentapyrroles, their preparation and use | ||
| 摘要 | The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina. | ||
| 申请公布号 | US9637450(B2) | 申请公布日期 | 2017.05.02 |
| 申请号 | US201414775540 | 申请日期 | 2014.03.13 |
| 申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | Petrukhin Konstantin;Cioffi Christopher;Johnson Graham;Dobri Nicoleta;Freeman Emily;Chen Ping;Conlon Michael;Zhu Lei |
| 分类号 | C07D209/02;A61K31/454;C07D403/12;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/06;C07D471/04;C07D487/04;C07D498/04;C07D209/52 | 主分类号 | C07D209/02 |
| 代理机构 | Cooper & Dunham LLP | 代理人 | White John P.;Cooper & Dunham LLP |
| 主权项 | 1. A compound having the structure: wherein ψ is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and isand wherein when ψ is present, then R6 is absent and when ψ is absent, then R6 is present, or a pharmaceutically acceptable salt thereof. | ||
| 地址 | New York NY US | ||