Foamable vehicle and pharmaceutical compositions thereof

摘要

A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of less than 0.9 or about 0.9 to about 0.7 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

主权项

1. A foamable pharmaceutical composition in a container comprising:
i) a carrier composition comprising:
a) at least one polar solvent selected from the group consisting of:
a polyethylene glycol (PEG) and a polyol, wherein the polar solvent is at a sufficient concentration to provide an Aw value of the pharmaceutical composition of less than 0.9 or about 0.9 to about 0.7;b) a foam adjuvant;c) a hydrophobic solvent comprising an oil selected from the group consisting of a mineral oil, isopropyl palmitate, isopropyl isostearate, diisopropyl adipate, diisopropyl dimerate, a maleated soybean oil, octyl palmitate, cetyl lactate, cetyl ricinoleate, tocopheryl acetate, acetylated lanolin alcohol, cetyl acetate, phenyl trimethicone, glyceryl oleate, tocopheryl linoleate, wheat germ glycerides, arachidyl propionate, myristyl lactate, decyl oleate, propylene glycol ricinoleate, isopropyl lanolate, pentaerythrityl tetrastearate, neopentylglycol dicaprylate/dicaprate, isononyl isononanoate, isotridecyl isononanoate, myristyl myristate, triisocetyl citrate, octyl dodecanol, an olive oil, a canola oil, a cottonseed oil, a coconut oil, a sesame oil, a sunflower oil, a borage seed oil, a syzigium aromaticum oil, a hempseed oil, a herring oil, a cod-liver oil, a salmon oil, a flaxseed oil, a wheat germ oil, an evening primrose oils, an essential oil and mixtures of any two or more thereof; andd) water; and ii) a liquefied or compressed gas propellant;
wherein the composition does not contain a gelling agent; wherein the composition comprises less than 5% by weight of the carrier composition of a short chain alcohol; and wherein the foamable pharmaceutical composition forms a uniform foam upon release from the container.