Method for producing hexafluoroisopropanol and fluoromethyl hexafluoroisopropyl ether (sevoflurane)

摘要

Disclosed is a method for producing a hexafluoroisopropanol, including the steps of (a) purifying a mixture containing hexafluoroacetone and at least 1,1,1-trifluoro-2,2-dichloroethane as an impurity, thereby obtaining a purified hexafluoroacetone containing 120 ppm or lower of the 1,1,1-trifluoro-2,2-dichloroethane; and (b) bringing hydrogen (H2) into contact with the purified hexafluoroacetone in the presence of a catalyst, thereby hydrogenating the hexafluoroacetone into the hexafluoroisopropanol. It is possible by this method to produce the hexafluoroisopropanol with a short reaction time and a high conversion. Therefore, it is possible to particularly advantageously produce fluoromethyl hexafluoroisopropyl ether (sevoflurane) by using the hexafluoroisopropanol produced by the method.

主权项

1. A method for producing a fluoromethyl hexafluoroisopropyl ether (sevoflurane), comprising the steps of:
(a) purifying a mixture containing hexafluoroacetone and greater than 120 ppm of 1,1,1-trifluoro-2,2-dichloroethane as an impurity, thereby obtaining a purified hexafluoroacetone containing 5-120 ppm of the 1,1,1-trifluoro-2,2-dichloroethane; (b) bringing hydrogen (H2) into contact with the purified hexafluoroacetone in the presence of a catalyst, thereby hydrogenating the hexafluoroacetone into a hexafluoroisopropanol; and (c) reacting the hexafluoroisopropanol, formaldehyde, and hydrogen fluoride in the presence of a Lewis acid or a Broensted acid.