| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: Z is N or CR1, where 1e is selected from H, halo, C1-4 alkyl and C1-4 haloalkyl; R2 and R3 are independently selected from C1-4 alkyl and C1-4 haloalkyl, R4 is H or C1-4 alkyl; X is selected from H, halo, C1-4 alkyl, C1-4 haloalkyl, and CN; L is selected from —CR5═CR6—, —O—, —S—, and a direct bond between A and the ring containing Z; R5 and R6 are independently selected from H, halo, C1-4 alkyl, and C1-4 haloalkyl; and A is halo, CN, or an optionally substituted group selected from C1-4 alkyl, C3-6 cycloalkyl, phenyl, C2-6 alkenyl, C2-6 alkynyl, 5-6 membered heteroaryl containing up to four heteroatoms selected from N, O and S as ring members, and 4-6 membered heterocyclyl containing up to two heteroatoms selected from N, O and S as ring members,
wherein the C1-4 alkyl, C3-6 cycloalkyl, phenyl, C2-6 alkenyl, C2-6 alkynyl, 5-6 membered heteroaryl containing up to four heteroatoms selected from N, O and S as ring members, and 4-6 membered heterocyclyl containing up to two heteroatoms selected from N, O and S as ring members are each optionally substituted with up to three groups selected from halo, hydroxy, CN, R10, —(CH2)0-2OR10, —SR10, —S(O)R10, —SO2R10, —S(O)(NH)R10, and —(CH2)0-2N(R10)2;where each R10 is independently H or C1-4 alkyl optionally substituted with one or two groups selected from amino, hydroxy, C1-4 alkoxy, and CN; and —N(R10)2 can represent a 5-6 membered heterocyclic ring optionally containing an additional heteroatom selected from N, O and S as a ring member, and optionally substituted with one or two groups selected from oxo, halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, and amino. |
