Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives

摘要

The present invention concerns novel compounds of Formula (I):;
wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

主权项

1. A compound of Formula (I) or a stereoisomeric form thereof, wherein R1 is hydrogen, chloro or fluoro; R2 is hydrogen, chloro, fluoro or methyl; R3 and R4 are hydrogen; or R3 and R4 taken together form a bond; R5 is 1,1-difluoroethyl, and R6 is hydrogen or fluoro; or R5 is hydrogen or fluoro, and R6 is 1,1-difluoroethyl; or a pharmaceutically acceptable addition salt or a solvate thereof.