| 主权项 |
1. A compound of Formula (I)wherein
U is CR1 or N; X is CR2 or N; Y is CR3 or N; Z is CR4 or N; R1 is independently H or deuterium; R2 is H, deuterium, optionally substituted (C1-C3)alkyl, or CF3; R3 is H, deuterium or optionally substituted (C1-C3)alkyl; R4 is H or deuterium; R5 is —R501-L-R502 wherein
R501 is a bond, —O—, —OCH2—, or optionally substituted (C1-C3)alkylene,L is —C(═O)—, —CH2N(H)C(═O)—, —N(H)C(═O)—, or —N(H)S(O)2; orL is a bond and R502 is —CN; orL is -L1-L2 wherein L1 is attached to R501 wherein
L1 is optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted saturated or partially saturated heterocyclyl, or optionally substituted saturated or partially saturated (C3-C7)cycloalkyl and L2 is a bond, —CH2N(Ra)—, —CH2N(Ra)C(O)—, —N(Ra)C(O)—, —N(Ra)S(O)2— or —N(Ra)—; orL1 is a saturated or partially saturated heterocyclyl containing one or more heteroatoms wherein at least one heteroatom is nitrogen and L2 is a bond, C(O) or —S(O)2—;R502 is H, CF3, OH, optionally substituted (C1-C6)alkyl, optionally substituted alkenyl, optionally substituted alkynyl, CN, or optionally substituted (C3-C6)cycloalkenyl; R6 is optionally substituted (C1-C6)alkyl, optionally substituted (C3-C12)cycloalkyl, optionally substituted phenyl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; or R6 is —R601-R602 wherein R601 is attached to the —N(H)— and
R601 is optionally substituted heteroaryl;R602 is N(Ra)2, optionally substituted (C1-C6)alkyl, optionally substituted (C3-C6)cycloalkyl, or optionally substituted heterocyclyl; and Ra is independently H or optionally substituted (C1-C6)alkyl;provided the compound is not 2-(3-{8-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-imidazo[1,2-a]pyridine-6-yl}-phenyl)-N-(5,5,5-trifluoro-4-hydroxy-4-methyl-pent-2-ynyl)-acetamide. |
