发明名称 |
GENETICALLY MODIFIED NON-HUMAN MAMMALS HAVING MODIFIED LIVER CELLS AND/OR TISSUE AND METHODS OF MAKING SAME |
摘要 |
Disclosed are non-human mammals having a modified liver and methods of making such non-human mammals having a modified liver. The modified liver may be characterized by a non-germline, stable integration of a non-endogenous gene targeted to the liver of the non-human mammal. In certain aspects, the modified liver may have greater than at least 30% ablation of the endogenous hepatocyte population of the non-human mammal. In certain aspects, the non-human mammal may comprise at least 30% non-endogenous hepatocytes. The disclosed non-human mammals may be useful for pharmacology, drug absorption, distribution, metabolism, and excretion studies, collectively ADME and toxicology studies (ADME-tox), and/or drug screening. |
申请公布号 |
US2017112108(A1) |
申请公布日期 |
2017.04.27 |
申请号 |
US201615299685 |
申请日期 |
2016.10.21 |
申请人 |
Hera Testing Laboratories, Inc. |
发明人 |
Crawford John Stuart;Yeshi Tseten;Noto Fallon |
分类号 |
A01K67/027;C12N7/00;C12N15/85;C12N15/86 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. A non-human mammal having a modified liver, wherein said modified liver is characterized by a non-germline, stable integration of a non-endogenous gene targeted to the liver of the non-human mammal. |
地址 |
Lexington KY US |