发明名称 RADIOLABELED COMPOUNDS
摘要 The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of CH24H in mammals. The compound of the present invention is represented by the formula (I): wherein each symbol is as defined in the specification.;
申请公布号 US2017114042(A1) 申请公布日期 2017.04.27
申请号 US201515316937 申请日期 2015.06.08
申请人 TAKEDA PHARMACEUTICAL COMPANY LIMITED 发明人 KOIKE Tatsuki;IKEDA Shuhei
分类号 C07D401/14;C07D417/14;C07D405/14;A61K51/04;C07D401/04 主分类号 C07D401/14
代理机构 代理人
主权项 1. A compound represented by the formula (I): wherein R1 is (1) a 3- to 8-membered monocyclic non-aromatic heterocyclic group substituted by 1 to 3 radiolabeled halogen atoms, or (2) an amino group mono- or di-substituted by substituent(s) selected from (a) a C1-6 alkyl group substituted by 1 to 3 radiolabeled halogen atoms, and(b) a radiolabeled C1-6 alkyl group, and optionally further substituted by a substituent selected from (c) a C1-6 alkyl group substituted by 1 to 3 halogen atoms,(d) a C1-6 alkyl group optionally substituted by C6-14 aryl group(s) optionally substituted by 1 to 3 halogen atoms,(e) a C3-8 cycloalkyl group, and(f) a 3- to 8-membered monocyclic non-aromatic heterocyclic group;R2 is (1) a C6-14 aryl group optionally substituted by 1 to 3 halogen atoms, or (2) a 5- or 6-membered monocyclic aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from (a) a halogen atom,(b) a C1-6 alkyl group, and(c) a C3-8 cycloalkyl group;X1 is CH or N; andRing A is or a salt thereof.
地址 Osaka JP