COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS

摘要

The present invention provides a compound of Formula I:;wherein X, Y, Z, R1 and R2 are as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with RAF kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

主权项

1. A compound of formula I:in which:
R1 is selected from hydrogen and methyl; R2 is selected from pyridinyl and phenyl; wherein phenyl or pyridinyl can be substituted with a group selected from trifluoromethyl, 1,1-difluoroethyl and 2-fluoropropan-2-yl; X and Y are independently selected from N and —OCH2CHR3R4; wherein R3 is selected from hydrogen and OH; and R4 is selected from 2-(phosphonooxy)methyl and phosphonooxy; with the proviso that if X is N, Y is —OCH2CHR3R4 and if Y is N, X is —OCH2CHR3R4; and Z is selected from N and CH; or a pharmaceutically acceptable salt thereof.