USES OF COMPOUNDS AND MIXTURES FROM ANTRODIA CINNAMOMEA MYCELIA

摘要

The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula;;and preferably are selected from
3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione,3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione,3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione,3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.

主权项

1. A method for inducing or enhancing liver regeneration, comprising administering to a subject in need thereof an effective amount of a composition comprising a compound having the formula or its tautomeric forms, its stereoisomers, its polymorphs, its salts, or its solvates, wherein X is N or O; R1 is H, hydroxyl, C1-10 alkyloxy, C2-10 alkenyloxy, or C2-10 alkynyloxy; R2 is H, hydroxyl, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; R3 is H, hydroxyl, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; denotes a single or double bond; provided that if X is O, R3 is absent; if denotes a single bond, the compound has the formula: