| 发明名称 | ROCK in combination with MAPK pathway | ||
| 摘要 | The current disclosure relates to pharmaceutical combinations and compositions useful in the treatment of certain types of cancer. The disclosure also relates to method of treatment these certain types of cancer. In particular, the disclosure relates to the combined use of inhibitors of ROCK and proteins of the MAPK/ERK-pathway in the treatment of KRAS-, NRAS- or BRAF-mutated cancer, in particular in NRAS mutated melanoma. | ||
| 申请公布号 | US9629851(B2) | 申请公布日期 | 2017.04.25 |
| 申请号 | US201415023229 | 申请日期 | 2014.09.22 |
| 申请人 | STITCHING HET NEDERLANDS KANKER INSTITUT—ANTONI VAN LEEUWENHOEK ZIEKENHUIS | 发明人 | Peeper Daniel Simon;Smit Marjon Antoinetta;Vogel Celia Jill |
| 分类号 | A61K31/551;A61K38/00;A61K31/4184;A61K31/437;A61K31/4409;A61K31/4439;A61K31/506;A61K31/519;A61K31/5377 | 主分类号 | A61K31/551 |
| 代理机构 | Browdy and Neimark, PLLC | 代理人 | Browdy and Neimark, PLLC |
| 主权项 | 1. A method for the treatment of a cancer selected from the group consisting of NRAS-, KRAS- and BRAF-mutated cancer, wherein the method comprises administering to a patient in need thereof a ROCK-inhibitor and an inhibitor of a protein of the MAPK/ERK pathway. | ||
| 地址 | Amsterdam NL | ||