发明名称 |
Compositions and methods for inhibiting expression of the ALAS1 gene |
摘要 |
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1. |
申请公布号 |
US9631193(B2) |
申请公布日期 |
2017.04.25 |
申请号 |
US201314391392 |
申请日期 |
2013.04.10 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC.;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
Bettencourt Brian;Fitzgerald Kevin;Querbes William;Yasuda Makiko;Desnick Robert J. |
分类号 |
C12N1/21;C12N15/113;A61K31/713 |
主分类号 |
C12N1/21 |
代理机构 |
Lando & Anastasi, LLP |
代理人 |
Lando & Anastasi, LLP |
主权项 |
1. A method of treating a disorder related to ALAS1 expression, comprising administering to a subject in need of such treatment a therapeutically effective amount of a double-stranded ribonucleic acid (dsRNA), wherein said dsRNA comprises a sense strand and an antisense strand, each of which are 15-30 nucleotides in length, wherein the antisense strand comprises a region of complementarity to an ALAS1 RNA and comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from SEQ ID NO: 1296, and wherein the antisense strand is complementary to at least nucleotides 871-889 of SEQ ID NO: 1. |
地址 |
Cambridge MA US |