2,3-butanediamide epoxide compound and preparation method and use thereof

摘要

Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.;

主权项

1. A compound of formula I, wherein: Y is independently —O—, —S—, —C(R4)2—, —N(R4)— or hydroxy, wherein when Y is hydroxy, Ar- is absent; R4 is independently hydrogen or C1-6 alkyl; Ar is independently cycloalkyl, heterocycloalkyl, aryl or heteroaryl, which is optionally and independently mono- or poly-substituted by 1, 2, 3, 4 or 5 R1; R1 is independently hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, cyanoalkyl, hydroxyalkyl, haloalkyl, haloalkoxy, alkylthio, cycloalkyl, heterocycloalkyl, alkoxycarbonyl or nitro; R2 is independently hydrogen, halogen, aryl or heteroaryl, wherein said aryl or heteroaryl is optionally and independently mono- or poly-substituted by 1, 2, 3, 4 or 5 substituents, and the substituents are independently hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, cyanoalkyl, hydroxyalkyl, haloalkyl, haloalkoxy, alkylthio, cycloalkyl, heterocycloalkyl, alkoxycarbonyl or nitro; R3 is independently hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, cyanoalkyl, hydroxyalkyl, haloalkyl, haloalkoxy, alkylthio, cycloalkyl, heterocycloalkyl, alkoxycarbonyl, nitro or a group of formula R5 is independently hydrogen or C1-6 alkyl; W is independently —C(R6)2—, —NR6)—, —O— or —S—; and R6 is independently hydrogen or C1-6 alkyl, or optical isomer, pharmaceutically acceptable salt, solvate or hydrate thereof.