| 摘要 |
Provided is a compound having a D-amino acid oxidase (DAAO) inhibitory action, and useful as, for example, a prophylaxis and/or therapeutic agent for schizophrenia or neuropathic pain. The present inventors have studied a compound that inhibits DAAO, and confirm that a dihydroxy aromatic heterocyclic compound has a DAAO inhibitory action, and completed the present invention. That is, the dihydroxy aromatic heterocyclic compound of the present invention has a good DAAO inhibitory action, and can be used as a prophylaxis and/or therapeutic agent for, for example, schizophrenia or neuropathic pain. |
| 主权项 |
1. An agent for the prophylaxis and/or treatment of a disease associated with DAAO, comprising a compound of the formula (I) or a salt thereof as an active ingredient: wherein X is CR2, Y is N, Z is CH, R1 is chosen from H, C1-10 alkyl, -lower alkylene-OR3, halogen, unsubstituted or substituted cycloalkyl, -L1--R4 or -L2-N(—R5)R6, R2 is chosen from lower alkyl, halogen or -lower alkylene-aryl, R3 is chosen from H or lower alkyl, L1 is chosen from -lower alkylene-, -lower alkenylene-, -lower alkylene-O—, -lower alkylene-S(O)m— or -lower alkylene-C(O)—, L2 is chosen from -lower alkylene-, -lower alkylene-S(O)2— or -lower alkylene-C(O)—, R4 is chosen from unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted nonaromatic heterocycle or unsubstituted or substituted aromatic heterocycle, R5 is chosen from H, lower alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl, R6 is chosen from lower alkyl, -L21-(unsubstituted or substituted cycloalkyl), -L21-(unsubstituted or substituted aryl), -L21-(unsubstituted or substituted nonaromatic heterocycle), -L21-(optionally unsubstituted or substituted aromatic heterocycle), -lower alkylene-OR7 or -lower alkylene-N(R8)2, R7 is chosen from H or lower alkyl, R8 are the same or different and each is lower alkyl, L21 is chosen from a bond or -lower alkylene-, and m is chosen from an integer of 0 to 2. |
