USE OF BIOMARKERS FOR DETECTION OF EXCESSIVE ALCOHOL USE

摘要

Methods of diagnosing excessive alcohol use are disclosed herein. More particularly, the present disclosure is directed to methods of diagnosing excessive alcohol use by identifying expression levels of various serum biomarkers. In some embodiments, expression levels of these biomarkers are affected by alcohol use even up to 30 days after consumption of alcohol.

主权项

1. A method for diagnosing excessive alcohol use in a subject, the method comprising:
obtaining a sample from a subject suspected of excessive alcohol use; contacting the sample with an agent that specifically binds to a biomarker selected from the group consisting of AT-Rich Interactive Domain-Containing Protein 4B (ARID4B), phosphatidylcholine-sterol acyltransferase (LCAT), hepatocyte growth factor-like protein (MST1), ADP-ribosylation factor 6 (ARL6), sCD14, sCD163, and neopterin, and combinations thereof, to form a complex between the agent and biomarker; detecting the complex to determine an expression level of the biomarker in the sample; and diagnosing excessive alcohol use in the subject if the expression level of the biomarker is increased as compared to the expression level of the biomarker in a reference sample.