| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:
Ar1 is Ar1 is optionally substituted with w occurrences of —W—RW; wherein
each W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by —CO—, —O—, —S—, —SO2—, or —NR′—;each R′ is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; andeach RW is independently H, halo, CN, NO2, NH2, CF3, OCF3, OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, aryl, or heteroaryl, wherein, when substituted, Rw is substituted with up to two R2;each R2 is halo, CN, NO2, CF3, OCF3, OR, —(C1-C6)alkylidene-OH, —(C1-C6)alkylidene-N(R)2, OC(O)R, OC(O)N(R)2, SR, S(O)R, SO2R, SO2N(R)2, SO3R, C(O)R, CO2R, C(O)N(R)2, N(R)2, NRC(O)R, NRCO2R, NRC(O)N(R)2, NRSO2R, B(OR)2, or NRSO2N(R)2;each R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl;RN is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl;A is an optionally substituted 3-7 membered monocyclic ring;B is optionally fused to a 5-7 membered ring selected from cycloaliphatic, aryl, heterocyclic, and heteroaryl;J is selected from CH2, CF2, C(CH3)2, C(O), C(Phenyl)2, B(OH), and CH(OEt); andw is independently an integer from 0 to 5 inclusive. |
