发明名称 AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
摘要 Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula:;;or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(═O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.
申请公布号 US2017107219(A1) 申请公布日期 2017.04.20
申请号 US201615390933 申请日期 2016.12.27
申请人 Shionogi & Co., Ltd. 发明人 KOJIMA Eiichi;Tonogaki Keisuke;Tanaka Nobuyuki;Katou Manabu;Ino Akira;Iwatsu Masafumi;Fujioka Masahiko;Hinata Yu;Ohyabu Naoki
分类号 C07D471/04;C07F9/6561 主分类号 C07D471/04
代理机构 代理人
主权项
地址 Osaka-shi JP