| 发明名称 |
Methods of killing cells and use of same in prevention and treatment of cancer |
| 摘要 |
A method of killing a cell having a mutation in an Adenomatous polyposis coli (APC) gene is disclosed. The method comprises contacting the cell with an inhibitor of Casein kinase I (CKI), the CKI being selected from the group consisting of CKI-alpha and CKI-delta and CKI-epsilon, thereby killing the cell. The method may be used for treating cancers. Pharmaceutical compositions for treatment of cancers are also disclosed. |
| 申请公布号 |
US9623109(B2) |
申请公布日期 |
2017.04.18 |
| 申请号 |
US200912994856 |
申请日期 |
2009.05.26 |
| 申请人 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
发明人 |
Ben-Neriah Yinon;Elyada Ela;Pribluda Ariel |
| 分类号 |
A61K45/06 |
主分类号 |
A61K45/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preventing colorectal cancer in a subject having a mutation in an Adenomatous polyposis coli (APC) gene, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of Casein kinase I (CKI), said CKI being selected from the group consisting of CKIα and CKIδ, thereby preventing the colorectal cancer. |
| 地址 |
Jerusalem IL |
