发明名称 Large stokes shift dyes
摘要 Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
申请公布号 US9624424(B2) 申请公布日期 2017.04.18
申请号 US201414566166 申请日期 2014.12.10
申请人 Life Technologies Corporation 发明人 Hu Yi-Zhen;Kang Hee Chol
分类号 C07D403/06;C07D413/06;C07D417/06;C09K11/06;C07D209/14;C07D401/14;C09B23/01;C09B23/08;G01N33/52;C07D209/26;C07D401/10;C07H19/207 主分类号 C07D403/06
代理机构 代理人
主权项 1. A compound of Formula I or II: or a salt thereof; wherein R1 and R2, when taken alone, are independently, halo, hydroxyl, amino, C1-6 alkylamino, C2-12 dialkylamino, C1-6 perfluoroalkyl, C1-6 alkyl, or C1-6 alkoxy; R3 and R4 are (CH2)3SO3H; R5 and R6, when taken alone, are independently H, C1-6 carbonyl or substituted C1-6 alkyl, wherein at least one of R5 and R6 is C1-6 alkyl substituted with a substituent selected from the group consisting of SO3H, COOH, OH, and NH2, maleimide, thiol, isocyanate, isothiocyanate, disulfide, alkynyl, azidoyl and trialkoxysilane; R7 and R8 are independently H, C1-4 alkyl, or phenyl; X and Y are independently CR92, NR10, O or S; and each R9 and R10 is independently C1-4 alkyl.
地址 Carlsbad CA US