| 主权项 |
1. A compound of formula Iwherein
X is W is N or CR10; Y is N or CR11; V is N or CR12; R1 is optionally substituted aryl-C1-C10-alkyl, or optionally substituted aryl; R2 is —CO2H, optionally substituted heterocyclyl, optionally substituted —CONHSO2R14, optionally substituted —CONHCOR13, optionally substituted —SO2NHCOR13 or optionally substituted —NHSO2R14; R13 is optionally substituted C1-C10 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C2-C10 alkenyl or optionally substituted C2-C10 alkynyl; R14 is CF3 or optionally substituted C1-C10 alkyl; R3 is H, halo, CN, optionally substituted C1-C10 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C2-C10 alkenyl or optionally substituted C2-C10 alkynyl; R4 is H or optionally substituted C1-C10 alkyl; R5 and R6 are independently H, optionally substituted C1-C10 alkyl or OH, or R5 and R6 are taken together with the carbon to which they are attached to form R7 and R8 are independently H, optionally substituted C1-C10 alkyl, optionally substituted C1-C10-alkoxy-C1-C10-alkyl, optionally substituted C1-C10 alkoxy, optionally substituted aryl, optionally substituted aryl-C1-C10-alkyl, optionally substituted 5- to 8-membered heteroaryl, or optionally substituted C3-C8 cycloalkyl; R9 is optionally substituted aryl, optionally substituted C1-C10 alkylaryl, optionally substituted C1-C10 alkoxyaryl, optionally substituted heteroaryl, optionally substituted C1-C10-alkyl heteroaryl, optionally substituted aryl-C1-C10-alkylaryl, optionally substituted aryloxyaryl, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C4-C8 cycloalkenyl; R10, R11 and R12 are H;and/or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. |
