Foamable composition combining a polar solvent and a hydrophobic carrier

摘要

The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.;The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

主权项

1. A method of treating or alleviating a disorder, the method comprising:
(a) releasing a foamable composition from a pressurized container to form a breakable foam that is stable at skin temperature and breaks upon application of shear force, said foamable composition comprising at least one liquefied or compressed gas propellant and a therapeutic composition comprising:
(1) a liquid organic carrier, at a concentration of about 10% to about 70% by weight of the therapeutic composition, wherein said liquid organic carrier comprises:
i. at least one liquid hydrophobic organic carrier; andii. a liquid polar solvent comprising ethanol and glycerin;wherein the hydrophobic organic carrier comprises isopropyl myristate;wherein the weight ratio between the liquid polar solvent and the at least one liquid hydrophobic organic carrier is between about 1:4 and about 4:1;(2) at least one surface-active agent selected from the group consisting of at least one non-ionic surface-active agent and a mixture of a non-ionic surface-active agent and an ionic surface-active agent, wherein the ratio of the non-ionic surface-active agent to the ionic surface-active agent is about 6:1 or greater than 6:1;(3) at least one polymeric agent selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent, a phase change agent, and any mixtures of two or more thereof;(4) water; and(5) an active agent comprising coal tar or a coal tar extract or a tincture dissolved in all or part of the liquid polar solvent;wherein the at least one liquefied or compressed gas propellant is at a concentration of about 3% to about 25% by weight of the foamable composition, (b) applying the breakable foam to a target area having a dermatological or mucosal disorder; the disorder being selected from the group consisting of eczema, psoriasis, pruritis, dandruff, seborrhoeic dermatitis, and combinations of two or more thereof; and (c) collapsing the breakable foam by applying shear force, wherein the foam is absorbed into the target area.