| 主权项 |
1. A compound having the structure of Formula I:
OP-Peptide-Linker-CP (I) or a salt thereof, wherein OP represents the structure ofcorresponding to that of a reactive organic phosphorous compound covalently modifying a tyrosine residue hydroxyl group of the peptide of Formula I, wherein P is in the Sp or Rp configuration, or a mixture thereof;
R is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, halogen, hydroxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycle, or optionally substituted amino; R′ is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocycle; X is oxygen, sulfur, selenium or imino; Peptide is a sequence of amino acids of a serum albumin protein comprising the tyrosine residue hydroxyl group that is modified to have the OP structure, wherein the peptide is comprised of a sequence of amino acids that mimics the active site of a tyrosine containing protein where the reactive organic phosphorous compound binds in human serum albumin, wherein the total number of amino acid residues in the sequence ranges from 7 to 41; Linker is an amino acid residue or a residue from another bifunctional residue capable of covalently linking an OP-peptide to a CP of formula I; and CP is a carrier protein wherein the carrier protein is suitable for display of haptens for generation of antibodies selective and specific for an OP-peptide. |
