COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES

摘要

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.;

主权项

1. A composition for therapeutic use, the composition comprising a 2-(acylamino)imidazole compound selected from the group consisting ofand salts thereofwherein:
R1 is a member selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl; X is a member selected from the group consisting of a bond, O, and NRSa; Y is a member selected from the group consisting of O, S, or NR5b; wherein when X is O or a bond, Y is O; R2 is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, arylalkyl, acyl, and carbamoyl; R3 is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, and arylalkyl; R4a and R4b are each a member independently selected from the group consisting of hydrogen, alkyl, fluoro, fluoroalkyl, alkenyl, aryl, and heteroaryl; or, alternatively, the two R4 join to form a spirocycloalkyl ring; R5a and R5b are each a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, arylalkyl, and heteroarylalkyl; each An of the An members is independently selected from the group consisting of N and CR6n; each of the R6n members is independently selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, aminoalkoxy, alkylamino, alkylaminoalkoxy, alkenyl, alkynyl, aryl, aryloxy, arylamino, cycloalkyl, cycloalkylalkyl, cycloalkoxy, cycloalkylalkoxy, cycloalkylamino, cycloalkylalkylamino, heterocyclyl, heterocycyloxy, heterocyclylamino, halo, haloalkyl, fluoroalkyloxy, heteroaryl, heteroaryloxy, heteroarylamino, arylalkyl, arylalkyloxy, arylalkylamino, heteroarylalkyl, heteroarylalkyloxy, and heteroarylalkylamino; or, alternatively, a pair of adjacent R6n members join to form an additional fused ring that is selected from the group consisting of cycloalkyl, aryl, heterocyclyl, and heterocycloaryl; and R7 is a member independently selected from the group consisting of alkyl, aminoalkyl, alkenyl, arylalkyl, and heteroarylalkyl; wherein the 2-(acylamino)imidazole compound is not a natural product.