| 摘要 |
A bioadhesive strip includes material that is removable or dissolvable in the oral cavity and adheres to the mucosal tissue of a person's oral cavity, with preferred embodiments including a specially textured surface on at least the outer side of an adhesive strip that faces away from the mucosal tissue to which it is attached and that has anti-microbial characteristics, bioluminescent expressions, etc. and a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human's mouth. Methods of using the bioadhesive strip include treating snoring, sore throat conditions, GERD, NAFLD, Alzheimer's Disease, cachexia and migraines. |
| 主权项 |
1. A buccal bioadhesive strip, comprising: a strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 .mu.m in at least a portion of said at least one surface, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 3 hours while inside a person's mouth, said strip including at least one polymer selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and mixtures thereof; and wherein said strip includes between 0.2 and 0.9% xylitol by weight. |
