Method and topical formulation for treating localized edema

摘要

Methods and formulations are provided for the treatment of localized edema, particularly localized edema resulting from chronic venous insufficiency. A metal ion sequestrant is topically administered to a subject afflicted with localized edema in combination with a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide. Topically administrable formulations for use in the aforementioned method are also provided.

主权项

1. A method for treating localized edema in a patient, comprising:
topically applying to the patient at the site of the localized edema a composition consisting of (a) a therapeutically effective amount of a metal ion sequestrant, wherein the metal ion sequestrant is ethylenediamine tetraacetic acid (EDTA), and pharmacologically acceptable salts thereof, (b) an effective permeation-enhancing amount of a permeation enhancer selected from methylsulfonylmethane and a combination of methylsulfonylmethane and dimethylsulfoxide and (c) a pharmaceutically acceptable topical carrier consisting of one or more inactive additives, wherein the localized edema is caused by chronic venous insufficiency.