发明名称 |
Muscle stem cell or myoblast, method for screening substances that participate in metabolic conversion using same, and pharmaceutical composition comprising substance obtained from said screening method |
摘要 |
The object of the present invention is to provide a method for screening a substance involved in a metabolic shift of skeletal muscle, and a kit for screening a substance involved in a metabolic shift of skeletal muscle.;The object can be solved by a muscle stem cell or myoblast comprising at least one myosin-heavy chain fusion gene selected from the group consisting of a myosin-heavy chain I fusion gene wherein a myosin-heavy chain I gene and a fluorescent protein or photoprotein gene are fused, a myosin-heavy chain IIa fusion gene wherein a myosin-heavy chain IIa gene and a fluorescent protein or photoprotein gene are fused, a myosin-heavy chain IId/x fusion gene wherein a myosin-heavy chain IId/x gene and a fluorescent protein or photoprotein gene are fused, and a myosin-heavy chain IIb fusion gene wherein a myosin-heavy chain IIb gene and a fluorescent protein or photoprotein gene are fused. |
申请公布号 |
US9618502(B2) |
申请公布日期 |
2017.04.11 |
申请号 |
US201415031491 |
申请日期 |
2014.10.24 |
申请人 |
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
发明人 |
Shigemoto Kazuhiro |
分类号 |
G01N33/50;A61K31/436;A61K45/06;A61K31/198;A61K31/36;A61K38/18;A61K38/20;A61K38/00 |
主分类号 |
G01N33/50 |
代理机构 |
Heslin Rothenberg Farley & Mesiti PC |
代理人 |
Sheehan Teige P.;Heslin Rothenberg Farley & Mesiti PC |
主权项 |
1. A muscle stem cell or myoblast comprising at least one myosin-heavy chain fusion gene selected from the group consisting of:
a myosin-heavy chain I gene and a fluorescent protein or photoprotein gene, a myosin-heavy chain IIa gene and a fluorescent protein or photoprotein gene, a myosin-heavy chain IIdix gene and a fluorescent protein or photoprotein gene, and a myosin-heavy chain Hb gene and a fluorescent protein or photoprotein gene. |
地址 |
Tokyo JP |